IDAL member Prof. José D. Martín-Guerrero, and Prof. Dr. Lucas Lamata, from Universidad de Sevilla, are Guest Editors of a special issue in the journal Applied Sciences on Machine Learning and Physics. The deadline is 31st October 2021. We are welcoming original research papers, mini-reviews and perspective articles dealing with aspects in the fuzzy border between Physics and Machine Learning, particularly Quantum Machine Learning, Physics-inspired Machine Learning algorithms and applications of classical (and quantum) Machine Learning for different Physics applications. More info at https://www.mdpi.com/journal/applsci/special_issues/Machine_Learning_Physics.