Publications

Sánchez-Ortí, Joan Vicent; Balanzá-Martínez, Vicent; Correa-Ghisays, Patricia; Selva-Vera, Gabriel; Vila-Francés, Joan; Magdalena-Benedito, Rafael; San-Martin, Constanza; Victor, Víctor M.; Escribano-Lopez, Irene; Hernández-Mijares, Antonio; Vivas-Lalinde, Juliana; Crespo-Facorro, Benedicto; Tabarés-Seisdedos, Rafael

Specific metabolic syndrome components predict cognition and social functioning in people with type 2 diabetes mellitus and severe mental disorders Journal Article

In: Acta Psychiatrica Scandinavica, vol. n/a, no. n/a, 2022.

Abstract | Links | BibTeX

@article{https://doi.org/10.1111/acps.13433,

title = {Specific metabolic syndrome components predict cognition and social functioning in people with type 2 diabetes mellitus and severe mental disorders},

author = {Joan Vicent S\'{a}nchez-Ort\'{i} and Vicent Balanz\'{a}-Mart\'{i}nez and Patricia Correa-Ghisays and Gabriel Selva-Vera and Joan Vila-Franc\'{e}s and Rafael Magdalena-Benedito and Constanza San-Martin and V\'{i}ctor M. Victor and Irene Escribano-Lopez and Antonio Hern\'{a}ndez-Mijares and Juliana Vivas-Lalinde and Benedicto Crespo-Facorro and Rafael Tabar\'{e}s-Seisdedos},

url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.13433},

doi = {https://doi.org/10.1111/acps.13433},

year  = {2022},

date = {2022-04-13},

journal = {Acta Psychiatrica Scandinavica},

volume = {n/a},

number = {n/a},

abstract = {Abstract Objective Obesity and metabolic diseases such as metabolic syndrome (MetS) are more prevalent in people with type 2 diabetes mellitus (T2DM), major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ). MetS components might be associated with neurocognitive and functional impairments in these individuals. The predictive and discriminatory validity of MetS and its components regarding those outcomes were assessed from prospective and transdiagnostic perspectives. Methods Metabolic syndrome components and neurocognitive and social functioning were assessed in 165 subjects, including 30 with SZ, 42 with BD, 35 with MDD, 30 with T2DM, and 28 healthy controls (HCs). A posteriori, individuals were classified into two groups. The MetS group consisted of those who met at least three of the following criteria: abdominal obesity (AO), elevated triglycerides (TG), reduced high-density lipoprotein cholesterol (HDL), elevated blood pressure (BP), and elevated fasting glucose (FPG); the remaining participants comprised the No-MetS group. Mixed one-way analysis of covariance and linear and binary logistic regression analyses were performed. Results Cognitive impairment was significantly greater in the MetS group (n = 82) than in the No-MetS group (n = 83), with small effect sizes (p < 0.05; η²p = 0.02 \textendash 0.03). In both groups, the most robust associations between MetS components and neurocognitive and social functioning were observed with TG and FPG (p < 0.05). There was also evidence for a significant relationship between cognition and BP in the MetS group (p < 0.05). The combination of TG, FPG, elevated systolic BP and HDL best classified individuals with greater cognitive impairment (p < 0.001), and TG was the most accurate (p < 0.0001). Conclusions Specific MetS components are significantly associated with cognitive impairment across somatic and psychiatric disorders. Our findings provide further evidence on the summative effect of MetS components to predict cognition and social functioning and allow the identification of individuals with worse outcomes. Transdiagnostic, lifestyle-based therapeutic interventions targeted at that group hold the potential to improve health outcomes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

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Abstract Objective Obesity and metabolic diseases such as metabolic syndrome (MetS) are more prevalent in people with type 2 diabetes mellitus (T2DM), major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ). MetS components might be associated with neurocognitive and functional impairments in these individuals. The predictive and discriminatory validity of MetS and its components regarding those outcomes were assessed from prospective and transdiagnostic perspectives. Methods Metabolic syndrome components and neurocognitive and social functioning were assessed in 165 subjects, including 30 with SZ, 42 with BD, 35 with MDD, 30 with T2DM, and 28 healthy controls (HCs). A posteriori, individuals were classified into two groups. The MetS group consisted of those who met at least three of the following criteria: abdominal obesity (AO), elevated triglycerides (TG), reduced high-density lipoprotein cholesterol (HDL), elevated blood pressure (BP), and elevated fasting glucose (FPG); the remaining participants comprised the No-MetS group. Mixed one-way analysis of covariance and linear and binary logistic regression analyses were performed. Results Cognitive impairment was significantly greater in the MetS group (n = 82) than in the No-MetS group (n = 83), with small effect sizes (p < 0.05; η²p = 0.02 – 0.03). In both groups, the most robust associations between MetS components and neurocognitive and social functioning were observed with TG and FPG (p < 0.05). There was also evidence for a significant relationship between cognition and BP in the MetS group (p < 0.05). The combination of TG, FPG, elevated systolic BP and HDL best classified individuals with greater cognitive impairment (p < 0.001), and TG was the most accurate (p < 0.0001). Conclusions Specific MetS components are significantly associated with cognitive impairment across somatic and psychiatric disorders. Our findings provide further evidence on the summative effect of MetS components to predict cognition and social functioning and allow the identification of individuals with worse outcomes. Transdiagnostic, lifestyle-based therapeutic interventions targeted at that group hold the potential to improve health outcomes.

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Ai, Ming-Zhong; Ding, Yongcheng; Ban, Yue; Martín-Guerrero, José D.; Casanova, Jorge; Cui, Jin-Ming; Huang, Yun-Feng; Chen, Xi; Li, Chuan-Feng; Guo, Guang-Can

Experimentally realizing efficient quantum control with reinforcement learning Journal Article

In: Science China Physics, Mechanics & Astronomy, vol. 65, no. 5, pp. 250312, 2022, ISBN: 1869-1927.

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