EASY, FREE, OPEN

Rat Creatinine Clearance Calculator

from plasma creatinine and body weight

  • Avoid long experimental procedures
  • Minimize animal stress

Calculator

Between 0.001 and 15
Between 120 and 700

Estimated creatinine clearance (mL/min):

 
  • infoHow to use

    Just input the value(s) and click calculate!

    grid_on

    The calculator accepts either one or multiple values as input in each field, separated either by new lines, semicolons, or spaces. For instance, you can directly paste a whole row or column from a spreadsheet and calculate the results for all of the instances at the same time.

    build

    The input and output formats can be controlled in the Configuration tab.

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    If you are using this calculator in your phone, you can add it to your home screen by tapping your explorer's menu icon (3 dots in the upper right-hand corner) and tapping Add to homescreen.

  • buildConfiguration
    Output value separator:

    Output decimal separator:

About the project

The model

works on a similar concept to human glomerular filtration rate (GFR)-estimating formulas to provide rat estimated creatinine clearance (eClCr) from a single analytical parameter (i.e., plasma creatinine) measured in a spot blood sample, and a body habitus indicator (i.e., body weight).

is a neural network-based calculator developed from matched pCr, weight, and experimentally measured ClCr data trios from our historical records on male Wistar rats. When evaluated on the training (1165 samples), validation (389), and test sets (660), the model committed an average prediction error of 0.196, 0.178, and 0.203 mL/min and had a correlation coefficient of 0.863, 0.902, and 0.856, respectively.

The eClCr value provided by is therefore an accurate substitute for the measurement of creatinine clearance, a long and tedious procedure involving isolation of experimental animals in metabolic cages for 24 hours. thus reduces experimental time and cost, facilitates research, and minimizes animal stress in line with the 3Rs principles for a more humane animal research.

Neural Network
The paper

Pellicer-Valero, Ó. J., Massaro, G. A., Casanova, A. G., Paniagua-Sancho, M., Fuentes-Calvo, I., Harvat, M., Martín-Guerrero, J. D., Martínez-Salgado, C., & López-Hernández, F. J, Neural network-based calculator for rat glomerular filtration rate, Biomedicines, 10(3), 610-621, 2022, doi: 10.3390/biomedicines10030610

The authors
Oscar J. Pellicer-Valero
1
Giampiero A. Massaro
2 3 4 5
Alfredo G. Casanova
2 3 4 5
Isabel Fuentes
2 3 5
María Paniagua
2 3 4 5
Mykola Harvat
1
José D. Martín
1 §
Carlos Martínez-Salgado
2 3 5 7 §
Francisco J. López-Hernández
2 3 4 5 6 7 §

Privacy

We DO NOT collect, use, store or transfer any data. All the data you input here and the calculations are handled locally by your browser. If you want to help us improve by providing us with more data, keep reading!

Collaborate with us

Beyond a useful research tool, is an ongoing project open to the scientific community. Researchers and groups generating rat creatinine clearance data may get involved by:

Reach us at: flopezher@usal.es